![]() Oxidative and inflammatory stresses besides cell apoptosis and necrosis are considered the primary hallmarks of CDDP-nephrotoxicity. The mechanisms of CDDP-induced renal impairment are complicated. Altogether, these outcomes suggest that the administration of Tur conjugated with SeNPs is effective neoadjuvant chemotherapy to guard against the renal adverse effects that are associated with CDDP therapy. Tur-SeNPs treatment also restored the renal histological features attained by CDDP challenge and hindered renal apoptosis through decreasing the Bax levels and increasing Bcl-2 levels. Noteworthy, lessening of renal inflammation was exerted by Tur-SeNPs via lessening of IL-6 and TNF-α besides down-regulation of NF-κB gene expression in mouse kidneys. Furthermore, Tur-SeNPs ameliorated the renal oxidant status of CDDP group demonstrated by decreased MDA and NO levels along with elevated levels of SOD, CAT, GPx, GR, GSH, and gene expression levels of HO-1. ![]() Compared with the controls, Tur or Tur-SeNPs therapy remarkably decreased the kidney index along with the serum levels of urea, creatinine, Kim-1, and NGAL of the CDDP-injected mice. The results revealed that Tur-SeNPs counteracted CDDP-mediated serious renal effects in treated mice. N-acetyl cysteine NAC (100 mg/kg) was used as a standard antioxidant compound. ![]() Mice were orally treated with Tur extract (200 mg/kg) or Tur-SeNPs (0.5 mg/kg) for 7 days after administration of a single dose of CDDP (5 mg/kg, i.p.). The existing study was designed to explore the reno-therapeutic efficacy of turmeric (Tur) alone or conjugated with selenium nanoparticles (Tur-SeNPs) against CDDP-mediated renal impairment in mice and the mechanisms underlying this effect. Cisplatin (CDDP) is a commonly prescribed chemotherapeutic agent however, its associated nephrotoxicity limits its clinical efficacy and sometimes requires discontinuation of its use. ![]()
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